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Table 3 Patient-derived pediatric glioma tumor and normal brain tissue specimens analyzed

From: Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

 

TNC score

p-value

0

1

2

3

WHO-Grade (n = 50)

I

2

7

1

2

*0.05

II

1

1

3

2

III

1

1

2

6

IV

1

4

5

11

Recurrence (n = 13)

Yes

2

0

0

4

0.07

No

0

2

2

3

Progression free survival (n = 33)

15.2

15.2

19.9

5.7

*0.0179

K27 M Status (n = 50)

MT

1

11

4

13

*0.012

WT

4

2

7

8

Notch3 (n = 39)

Present

2

8

4

13

*0.029

Abscent

1

2

7

2

Notch1 (n = 48)

Present

4

8

8

15

0.57

Abscent

1

5

3

4

PDGFRa (n = 42)

1

0

2

4

3

0.68

2

1

5

5

6

3

2

5

2

7

  1. Descriptive statistical analysis of immunohistochemical (IHC) staining results. TNC expression was found to directly correlate with tumor histologic grade, with highest TNC expression in high-grade tumors (WHO III and IV, p = 0.05). TNC expression also directly correlated with clinical tumor recurrence (p = 0.07), and inversely correlated to progression free survival (p = 0.018). TNC over-expression was more common in H3K27 M mutant tumors (p = 0.012), and was associated with NOTCH3 immunopositivity (p = 0.012). Between groups comparison was performed using Fischer’s exact test. MT = H3K27 M positive, WT = H3K27 M negative. * = p < 0.05
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Acta Neuropathologica Communications

ISSN: 2051-5960

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