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Table 3 Patient-derived pediatric glioma tumor and normal brain tissue specimens analyzed

From: Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

  TNC score p-value
0 1 2 3
WHO-Grade (n = 50) I 2 7 1 2 *0.05
II 1 1 3 2
III 1 1 2 6
IV 1 4 5 11
Recurrence (n = 13) Yes 2 0 0 4 0.07
No 0 2 2 3
Progression free survival (n = 33) 15.2 15.2 19.9 5.7 *0.0179
K27 M Status (n = 50) MT 1 11 4 13 *0.012
WT 4 2 7 8
Notch3 (n = 39) Present 2 8 4 13 *0.029
Abscent 1 2 7 2
Notch1 (n = 48) Present 4 8 8 15 0.57
Abscent 1 5 3 4
PDGFRa (n = 42) 1 0 2 4 3 0.68
2 1 5 5 6
3 2 5 2 7
  1. Descriptive statistical analysis of immunohistochemical (IHC) staining results. TNC expression was found to directly correlate with tumor histologic grade, with highest TNC expression in high-grade tumors (WHO III and IV, p = 0.05). TNC expression also directly correlated with clinical tumor recurrence (p = 0.07), and inversely correlated to progression free survival (p = 0.018). TNC over-expression was more common in H3K27 M mutant tumors (p = 0.012), and was associated with NOTCH3 immunopositivity (p = 0.012). Between groups comparison was performed using Fischer’s exact test. MT = H3K27 M positive, WT = H3K27 M negative. * = p < 0.05