Fig. 3
From: Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice
AT8 and AT100 immunohistochemistry after unilateral hippocampal seeding with CTR CSF (a, g; d, k) and AD CSF (b, h; e, l) into P301S mice. Accumulation of AT8 (c, p = 0.013) and AT 100 (f, p = 0.036) positive dot-like structures in the DG ipsilateral to the injection site. Increase in AT8 (i, p = 0.039) and AT 100 (m, p = 0.018) positive dot-like structures in the fimbria. Numbers indicate dot like structures per area. Scale bar in e equals 150 μm in a, b, d and e; scale bar in l equals 37,5 μm in g, h, k, and l