From: Histologic, immunohistochemical, and molecular features of pituicytomas and atypical pituicytomas
Patient | Sequencing attempted | DNA adequate | Disease-Associated Variants^{b} | Variants of Uncertain Significance^{b} | RNA adequate | Abnormal fusion Transcripts | ||
---|---|---|---|---|---|---|---|---|
1 | Y | Y | BRAF c.1799 T > A p.(V600E) | VAF 7% |
ARID2 c.1672C > T p.(R558C) FLT3 c.2546G > A p.(R849H) |
VAF 4% VAF 3% | N/A | N/A |
NF1 c.7079_ 7082delTTAT p.(F2360Wfs*35) | VAF 13% |
IGF1R c.3897C > G p.(N1298K) MSH6 c.1157C > G p.(P386R) |
VAF 50% VAF 48% | |||||
TSC1 c.2074C > T p.(R692*) | VAF 2% |
PBRM1 c.2504G > A p.(R850H); RNF43 c.1114C > T p.(P372S) |
VAF 4% VAF 55% | |||||
2 | Y | N | N/A | N/A | N/A | N/A | ||
3 | Y | N | N/A | N/A | N/A | N/A | ||
4 | Y | N | N/A | N/A | N/A | N/A | ||
5 | Y | N | N/A | N/A | N/A | N/A | ||
6 | Y | N | N/A | N/A | N/A | N/A | ||
7 | Y | Y | HRAS c.182A > G p.(Q61R) | VAF 26% |
KIT c.287C > T p.(T96 M) PTCH1 c.3617G > A p.(R1206H) |
VAF 38% VAF 49% | Y | None |
8 | N | N/A | N/A | N/A | N/A | N/A | ||
9 | N | N/A | N/A | N/A | N/A | N/A | ||
10 (1)^{a} | N | N/A | N/A | N/A | N/A | N/A | ||
10 (2)^{a} | N | N/A | N/A | N/A | N/A | N/A | ||
10 (3)^{a} | Y | N | N/A | N/A | N/A | N/A | ||
10 (4)^{a} | Y | Y | None | KDR c.3937G > A p.(D1313N) | VAF 47% | N/A | N/A | |
11^{a} | Y | N | N/A | N/A | N/A | N/A |