Table 3 Next generation sequencing of pituicytomas

1

Y

Y

BRAF c.1799 T > A p.(V600E)

VAF 7%

ARID2 c.1672C > T p.(R558C)

FLT3 c.2546G > A p.(R849H)

VAF 4%

VAF 3%

N/A

N/A

NF1 c.7079_ 7082delTTAT p.(F2360Wfs*35)

VAF 13%

IGF1R c.3897C > G p.(N1298K)

MSH6 c.1157C > G p.(P386R)

VAF 50%

VAF 48%

TSC1 c.2074C > T p.(R692*)

VAF 2%

PBRM1 c.2504G > A p.(R850H);

RNF43 c.1114C > T p.(P372S)

VAF 4%

VAF 55%

2

Y

N

N/A

N/A

3

Y

N

N/A

N/A

4

Y

N

N/A

N/A

5

Y

N

N/A

N/A

6

Y

N

N/A

N/A

7

Y

Y

HRAS c.182A > G p.(Q61R)

VAF 26%

KIT c.287C > T

p.(T96 M)

PTCH1 c.3617G > A p.(R1206H)

VAF 38%

VAF 49%

Y

None

8

N

N/A

N/A

N/A

9

N

N/A

N/A

N/A

10 (1)^a

N

N/A

N/A

N/A

10 (2)^a

N

N/A

N/A

N/A

10 (3)^a

Y

N

N/A

N/A

10 (4)^a

Y

Y

KDR c.3937G > A p.(D1313N)

VAF 47%

N/A

N/A

11^a

Y

N

N/A

N/A