Fig. 2

Imaging and histologic features of Patient #2. a Preoperative MR imaging (axial T1 without contrast) showing a lesion in the right frontal lobe with an area of intrinsic T1 hyperintensity. b T1 with contrast image showing areas of contrast enhancement associated with the right frontal lobe lesion. c T2-FLAIR sequence showing a large area of T2 hyperintensity in the right frontal lobe, partially extending into the corpus callosum. d Microscopic sections of the tumor showing hypercellular brain parenchyma with glial tumor cells forming perivascular pseudorosettes. e Areas of the tumor showed an endocrinoid capillary network and microcalcifications. f Necrosis with pseudopalisading, consistent with glioblastoma, is also present