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Table 3 Case description of PIK3CA-mutant glioblastomas

From: PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

Case Age Sex Tumor at presentation Type of surgery KPS PIK3CA mutation MGMT IDH1 EGFR Other alterations PFS (mo.) OS (mo.)
1 67 M multicentric PR 90 H1047R u wt n.t. TP53 R248W 6.3 9.7
2 68 M gliomatosis biopsy 90 R88Q n.t. wt N   3.2 5.1
3 31 M leptomeningeal metastasis biopsy 90 H1047R n.t. wt N   6.6 10.9
4 42 F single lesion PR 100 R88Q m wt N TP53 R273C 12.4 54.9
5 72 F single lesion GTR 90 R88Q m wt N   5.3 10.6
6 35 F multicentric GTR 90 Q546R u wt amp   26.6 32.4
7 25 M multicentric biopsy 80 R88Q m wt N   6.9 19.1
8 65 F single lesion GTR 100 Q546K m wt N   7.6 36.9
9 43 M single lesion PR 90 E545K u wt N   5.7 11
10 32 M single lesion PR 100 H1047R m wt N   13.8 17.7*
11 54 M single lesion GTR 100 E542K m wt N   34.8* 34.8*
12 57 M gliomatosis biopsy 80 H1047Y m wt N   6.6 21.2
13 51 M single lesion GTR 100 H1047R m wt amp   14.9 31.1
  1. Abbreviations: M, male; F, female; PR, partial resection; GTR, gross total resection; KPS, Karnofsky performance status; n.t., not tested; IDH1, isocitrate dehydrogenase 1; MGMT, O6-methylguanine-DNA methyltransferase promoter methylation; m, methylated; u, unmethylated; wt, wild-type; amp, amplified; N, non-amplified; PFS, progression-free survival; OS, overall survival; mo., months; *censored at last follow-up