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Table 1 Patient and tumor characteristics

From: PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

  Total PIK3CA mutant PIK3CA wildtype P value
Number of patients 157 13 144  
(male patient) (91 male) (9 male) (82 male) 0.56
Age median 58 (23–85) mean 49.4 ± 15.9 mean 58.1 ± 12.1 0.02*
KPS score median 90 (60–100) mean 92.3 ± 7.3 mean 87.7 ± 10.4 0.048*
Gross total resection 69 (44.0%) 5 (38.5%) 64 (44.4%) 0.78
IDH1 mutation 12/157 (7.6%) 0/13 (0.0%) 12/144 (8.3%) 0.60
MGMT promoter methylation 60/120 (50.0%) 8/11 (72.7%) 52/109 (47.7%) 0.20
EGFR amplification 63/143 (44.1%) 2/12 (16.7%) 61/131 (46.6%) 0.07
  1. * Statistical significance: P ≤ 0.05
  2. Abbreviations: KPS, Karnofsky performance status; IDH1, isocitrate dehydrogenase 1; MGMT O6-methylguanine-DNA methyltransferase