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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model

Fig. 2

RDA and FDA tracers and DAPI counterstaining. Stereotaxic coordinates were anterior 2.8; lateral 1 and depth − 2.7, from dura mater. a RDA injection site in AONd in the right hemisphere. b FDA injection site in AONd in the left hemisphere. c Interhemispheric fibers were marked by FDA and RDA in the anterior commissure. d Example of ipsilateral RDA labeling and contralateral FDA labeling in right AON. e Example of ipsilateral FDA labeling and contralateral RDA labeling in left AON. f Example of ipsilateral RDA labeling and contralateral FDA labeling in right OB. Most of contralateral labeling from AONd was restricted to ventral regions of AON and closer regions of the granule cell layer (GrL) of the olfactory bulb. Images g, h, i and j show usual retrograde ipsilateral labeling in Pir, ACo, Tu and Ent (including pyramidal cells of CA1), respectively. Scale bar: a, b, d and e = 400 μm, c, g-j = 200 μm and f = 100 μm. For abbreviations, see list

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