Fig. 2

Change in gene expression profile during the evolution and fate of WM lesions in progressive MS. a Visualization of the transcriptional landscape of genes (n = 18,722) detected between MS and non-MS (dots in graph); significantly regulated (FDR < 0.05) genes are indicated in bright red and orange, where orange indicates log₂FC > 1 or < − 1. b The Venn diagram represents the number of overlapping and lesion-specific differentially expressed genes (FDR < 0.05) between white matter (WM) lesion types (active, inactive, remyelinating, chronic active) compared to control WM tissue. FDR: false discovery rate; FC: fold change