Fig. 2

Rate of neurofibrillary tangles (NFTs) in neurons of the basal nucleus of Meynert (BNM) of cardiovascular disease (CVD). (a, b) The 19 middle cerebral artery (MCA) territory infarct cases. (c, d) The 11 putaminal hemorrhage cases. (e, f) Other CVD cases. (a, c, e) Phosphorylated tau-immunoreactive (ptau+) neurons. (b, d, f) Gallyas Braak stain-positive (GB+) neurons. (a) In most cases (14/19, 74%), the ratio of ptau+ neurons in total neurons was higher on the BNM-affected side than on the unaffected side. The median rate was also significantly higher on the BNM-affected side than on the unaffected side (p < 0.01). (b) In most cases (16/19, 84%), the rate of GB+ neurons was higher on the BNM-affected side than on the unaffected side. The median rate was also significantly higher on the BNM-affected side than on the unaffected side (p < 0.01). (c) In most cases (11/12, 92%), the rate of ptau+ neurons was higher on the BNM-affected side than on the unaffected side. The median rate was significantly higher on the BNM-affected side than on the unaffected side (p < 0.01). (d) In all 11 cases (100%), the rate of GB+ neurons was higher on the BNM-affected side than on the unaffected side. The median the rate was significantly higher on the BNM-affected side than on the unaffected side (p < 0.01). (e, f) In the other CVD cases, there were no significant differences in ptau+ or GB+ BNM neurons on the affected and unaffected sides