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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Downregulation of miR-204 expression defines a highly aggressive subset of Group 3/Group 4 medulloblastomas

Fig. 5

Effect of miR-204 expression on in vitro and in vivo invasion potential of medulloblastoma cells. a. Representative Images of the Calcein-labeled cells on the lower side of the transwell insert membrane, post-invasion of the doxycycline treated miR-204 expressing or vector control polyclonal population of D283 and HD-MB03 cells. b. Y- axis indicates the percentage of the invaded cells of the miR-204 expressing polyclonal population as compared to the Vector Control population of the cells, evaluated by measuring fluorescence intensity of the invaded cells. c. Photographs of hematoxylin-eosin stained paraffin sections (sagittal section) of the orthotopic xenografts of doxycycline treated vector control cells and miR-204 expressing polyclonal population of D341 cells. Arrows show the vector control cells invading cerebellar folia boundary as compared to the cohesive margin of the miR-204 expressing cells. Yellow line indicates cerebellar folia margin. d. The scatter dot plot shows significant difference in the number of invasive fields per tumor in the miR-204 expressing tumors as compared to those expressing vector control D341 cells. **, *** indicate p ≤ 0.001 and p ≤ .0001 respectively

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