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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

Fig. 7

PFF treatment of primary neurons causes respiration defects. Mouse cortical neurons treated with αSyn monomer or PFF were subjected to the mitochondrial stress test measuring oxygen consumption rate. The differences in the basal and maximal respiration levels are shown in the bar graphs, which represent the average ± standard error of three independent experiments with 15–20 wells of cells per experiment. Statistical significance was determined by two-way ANOVA (for basal level, F = 33.66; p < 0.0001; for maximal level, F = 48.13; P < 0.0001)

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