Fig. 4
From: Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue
Head-to-head comparison of [F-18]-MK-6240 and [F-18]-AV-1451 phosphor screen autoradiographic binding patterns in adjacent section obtained from the same tissue material containing entorhinal cortex (#13) (a) and superior temporal sulcus (#13) (b) from AD cases. Both tracers exhibited comparable strong binding in regions containing tangles; MK-6240 signal was blocked by adding 500 nM unlabeled AV-1451 and AV-1451 signal was almost completely blocked by adding 500 nM unlabeled MK-6240. Scale bar = 1 cm