Fig. 1

[F-18]-MK-6240 phosphor screen images of brain slices from AD (#5, #7, #9, #16) (a), control (#1, #2) (b), CTE (#32, #33) (c), P301L mutation carrier (#21) (d), PSP (#25) (e), and PiD (#20) (f) cases. A strong [F-18]-MK-6240 binding was observed in cortical regions containing tangles from AD brains. No signal was detected in basal ganglia, a region free of tangles. The signal was blocked by adding unlabeled MK-6240. Slices from a control case free of pathology did not show detectable [F-18]-MK-6240 binding (b). [F-18]-MK-6240 binding was not detectable either in non-PHF tau-containing slices from CTE (c), P301L mutation carrier (d), PSP (e) and PiD (f) cases. Abbreviations: AD = Alzheimer’s disease; CTE = chronic traumatic encephalopathy; PSP = progressive supranuclear palsy; PiD = Pick’s disease. Scale bar = 1 cm