Fig. 1

Wildtype mice injected with α-synuclein PFFs tolerate LRRK2 inhibition with MLi-2. a Experimental design schematic. C57BL/6J mice aged 3 months were evaluated at baseline for grip strength, then treated with MLi-2 in diet or control diet 3 days prior to injection with α-synuclein PFFs. After injection, mice were aged a further 3 months, during which time they received constant exposure to control or MLi-2 treatment and were assessed for grip strength every month. At 3 months, mice were given terminal assessment on both grip strength and accelerating rotarod, then sacrificed and analyzed as described. b Mouse body weight was assessed once weekly during the study and was steady over the course of the study in both groups, following a slight drop after surgery. c Based on mouse body weights and estimated diet consumption from diet weights, mice received steady dosing during the study, with an average estimated dosage of 26.5 mg/kg/day. Plots are means +/− s.e.m.