Fig. 7
Emergence of a deficit in input-output response in CA3-CA1 synapses. a No significant differences between input-output response in APP/tTA mice reared on dox and control littermates (control n = 6, APP/tTA n = 6). b Normal input-output response in APP/tTA mice expressing APPSw,Ind for 2 weeks (control n = 7, APP/tTA n = 7). c Normal input-output response in APP/tTA mice expressing APPSw,Ind for 3 weeks (control n = 8, APP/tTA n = 8). d Reduced input-output response in APP/tTA mice expressing APPSw,Ind for 12 weeks (control n = 11, APP/tTA n = 11). e Reduced input-output response in APP/tTA mice expressing APPSw,Ind for 29 weeks (control n = 6, APP/tTA n = 6). Scale bar calibration: 5 ms, 0.5 mV