Fig. 2

EphB2 deficiency alters gene expression related to cell death, inflammation and synaptic transmission after stroke. WT and Ephb2^−/− mice (n = 3/group) were subjected to 60 min MCAO followed by 48 h of reperfusion. Total RNA was isolated from the ipsilateral brain hemisphere and processed for genome array analysis. Exemplary results (enrichment plots) for selected gene sets associated with (a, c) synaptic transmission, (b) cell death and (d) inflammation, the corresponding statistical values and excerpt of the corresponding heat maps are shown. NES, normalized enrichment score; p, P-value (ANOVA); FDR: false discovery rate