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Table 3 Preclinical studies on tau vaccines

From: A walk through tau therapeutic strategies

IMMUNOGEN ANIMAL MODEL IMPROVEMENT EFFICACY REFERENCE
Cognitive Sensorimotor NFT’s Insoluble tau
Tau379–408 [pS396,404] P301L No change Improved Decreased Decreased [14]
Tau 379-408 [pS396/404] htau/PS1M146L Improved Improved Reduced Reduced [36]
Tau 417-426 [pS422] Thy-Tau22 Improved nd. Reduced Reduced [326]
Tau393-408 [pS396/S404] (Liposome based) P301L nd. Improved No change Reduced [322]
Tau379-408 [pS396/S404] hTau X PS1 Improved No change Reduced Reduced [37]
hTau Improved No change No change Reduced
hTau/PS1/mTau Improved No change No change Reduced
Tau195-213 [pS202/T205] DM-Tau-tg nd. nd. Reduced nd. [30]
Tau207-220 [pT212/S214] nd. nd. Reduced nd.
Tau 224-238 [pT231] nd. nd. Reduced nd.
Tau aa395-406 [pS396/404] pR5 nd. nd. Reduced nd. [25]
Human paired helical filaments (PHF’s) THY-Tau22 nd. nd. Reduced Reduced [12]
Tau229-237 [pT231/pS235] P301S nd. nd. nd. nd. [273]
Tg2576
Tau199–208 [pS202/pT205] P301S nd. Improved No change No change [274]
nd. Improved No change No change
Tau209–217 nd. Improved No change No change
Tau 294-305 SHR72 rats nd. Improved Reduced Reduced [167]
Tau 379-408 [pS396/404] 3xTg-AD No change nd. Reduced Reduced [270]
Tau 294-305 P301S Improved   Reduced Reduced [157]
  1. nd Not defined