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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene

Fig. 4

Biochemical studies. a RT-QuIC analysis: 15 μL of CSF collected from patients 1, 2 and 3 efficiently seeded the aggregation of recHaPrP (90–231) while CSF collected from patient with AD (referred to as control) did not. The mean ThT fluorescence values per sample were plotted against time. b Western blot analysis: frozen samples of frontal (GC) and cerebellar (CC) cortex from Case 1 showed the presence of type 1 PrPSc after digestion with PK (50 μg/mL). Frontal cortex of patients with type 1 and type 2 PrPSc were used as migration controls. Numbers on the right side of the WB indicate the molecular weight

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Acta Neuropathologica Communications

ISSN: 2051-5960

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