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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Fig. 3

– Neurodegeneration Within Layers of the Neurosensory Retina of rTg4510 Mice. a Differences in nuclear density (nuclei per tissue area) in the Retinal Ganglion Cell Layer (RGCL) of the central and peripheral retina of wildtype and rTg4510 mice. Two-way ANOVA (n = 6, F1,1 = 22.73, p = 0.0002). b Relative thickness (% of total neural retina) of the Inner Plexiform Layer (IPL) of the central and peripheral retina of wildtype and rTg4510 mice, as ascertained from H&E staining. Two-way ANOVA (n = 6, F1,1 = 0.00002853, p = 0.9958). c Differences in nuclear density (nuclei per tissue area) in the Inner Nuclear Layer (INL) of the central and peripheral retina of wildtype and rTg4510 mice. Two-way ANOVA (n = 6, F1,1 = 0.3358, p = 0.5704). Statistical significance indicated with asterisks: ** = p < 0.01; *** = p < 0.001, **** = p < 0.0001

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