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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Fig. 2

Quantification of Tau and pTau Immunoreactivity in the Neurosensory Retina of rTg4510 Mice. a Normalised (to total cells analysed) quantification of the percentage of cells displaying with pTau immunopositive cytosolic staining in the Retinal Ganglion Cell Layer (RGCL) and Inner Nuclear Layer (INL) of the central and peripheral retina. Two-way ANOVA (n = 3/4, F1,3 = 31.78, p < 0.0001). b Confocal z-stacked images demonstrating the flame-shaped morphology of cytosolic pTau inclusions in the RGCL and INL (indicated by white arrows) and bead-like neurite inclusions. Scale bars equal to 50 μm. Immunoreactive intensity (intensity per image pixel) of pTau in the RGCL, Inner Plexiform Layer (IPL), INL, and inner segment of the Photoreceptor Layer (PIS) in the (c) central neurosensory retina (two-way ANOVA (n = 3/4, F1,3 = 20.08, p = 0.0002)) and (d) peripheral retina (two-way ANOVA (n = 4, F1,3 = 63.03, p < 0.0001)). e Comparison of immunoreactive intensity between the central and peripheral regions of the neurosensory retina in the RGCL, IPL, INL and PIS layers of the rTg4510 mice (paired t-tests). Statistical significance indicated with asterisks: * = p < 0.05; ** = p < 0.01; *** = p < 0.001

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