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Table 1 Demographic, clinical (time point 1, 2 & 3) and post-mortem characteristics

From: Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration

  CTL AD
Time point 1 2 3 1 2 3
No. 15 12 4 57 57 32
Age, years 86 [79, 87] 88 [83, 90] 90 [89, 95] 83 [77, 88] 84 [78, 89] 87 [79, 89]
Gender, M/F 6/9 7/5 3/1 22/35 22/35 11/21
MMSE 29 [28.5, 30] 29 [28, 30] 29 [28, 29.3] 17 [9, 22] 14 [6, 20] 8 [4, 15]
APOE, ε4 carriers 5/14 (36%) 5/12 (42%) 2/4 (50%) 33/54 (61%) 33/54 (61%) 19/32 (59%)
NfL, pg/mL 29 [23, 34.5] 33 [29.3, 47] 39.3 [33, 45] 42 [33, 57] 48.3 [32, 67] 65 [47.3, 87]
Time to post-mortem, years 7 [3, 8] 7 [4, 8] 6.5 [6, 8] 4 [3, 6] 3 [2, 5] 2 [1, 3]
Braak staging Transentorhinal (I/II) 8 7 3 2 2 0
Limbic (III/IV) 4 3 0 11 11 4
Isocortical (V/VI) 3 2 1 44 44 28
  1. MMSE was found to be lower among CTL subjects, as compared to AD, across all three time points (p < 0.001)
  2. Plasma NfL was higher among AD subjects, relative to controls, at time point 1 (p < 0.01) and at both second and third time points (p < 0.05)