Fig. 6
From: Co-occurrence of chronic traumatic encephalopathy and prion disease
Conformational stability immunoassay of resPrPD. a: No significant difference was detected between each of the CTE cases 1–3 and their controls (n = 3) in PK-resistance following exposure to GdnHCl. As expected, stability of resPrPD associated with sCJDMM1 and sCJDMM2 were both significantly different. Mean [GdnHCl]½ molar values in CTE case 1–3 and controls were: 1.77 and 1.98 ± 0.08 respectively; 1.61 and 1.62 ± 0.09; and 2.01 and 1.95 ± 0.05 respectively. In sCJDMM1 and sCJDMM2 mean [GdnHCl]½ molar values were 1.95 ± 0.05 and 1.39 ± 0.17, respectively. * p ≤ 0.05. b: Immunoblots probed with 3F4 at increasing GdnHCl concentrations