Table 2 Associations between TDP-43 and Alzheimer’s disease pathologies using binary logistic regression (n = 929)
Region | OR (95% CI)a | P-value |
|---|---|---|
Diffuse plaques (moderate + frequent vs. no + sparse) | ||
Amygdala | 3.34 (1.47–8.99) | 0.0079 |
Hippocampus | 1.45 (0.81–2.71) | 0.23 |
EC/inferior TCTX | 2.61 (1.20–6.53) | 0.025 |
Frontal neocortex | 2.30 (0.63–14.93) | 0.28 |
Neuritic plaques (moderate + frequent vs. no + sparse) | ||
Amygdala | 2.84 (1.57–5.44) | 9.1 × 10 − 4 |
Hippocampus | 2.56 (1.58–4.29) | 2.2 × 10 − 4 |
EC/inferior TCTX | 4.04 (2.11–8.43) | 6.6 × 10 − 5 |
Frontal neocortex | 1.88 (0.71–5.92) | 0.23 |
Thal Aβ phase (phase 4 + 5 vs. phase 0 to 3) | ||
Amygdala | 2.78 (1.56–5.21) | 8.5 × 10 − 4 |
Hippocampus | 2.34 (1.44–3.93) | 8.5 × 10 − 4 |
EC/inferior TCTX | 2.52 (1.41–4.77) | 0.0029 |
Frontal neocortex | 1.42 (0.53–4.50) | 0.51 |
Braak NFT stage (stage V + VI vs. stage 0 to IV) | ||
Amygdala | 3.38 (1.99–5.95) | 1.3 × 10 − 5 |
Hippocampus | 2.90 (1.86–4.63) | 4.2 × 10 − 6 |
EC/inferior TCTX | 3.15 (1.86–5.53) | 3.4 × 10 − 5 |
Frontal neocortex | 1.22 (0.52–3.06) | 0.66 |