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Table 2 Variations of brain amyloid peptide level in APPSWE and WT mice after 5-HIAA or 5-HTP treatment

From: 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease

  WT NT WT 5HIAA Tg NT Tg 5HIAA Tg 5HTP  
Aβ40 109.2 88.6 3285 1996 1031 Mean (pg/total proteins)
100 81 100 61 31 Mean compared with NT (%)
0 −19 0 −39 −69 % of variation compared to corresponding NT
Aβ42 25.2 15.3 2544 2192 1408 Mean (pg/total proteins)
100 61 100 86 55 Mean compared with NT (%)
0 −39 0 −14 −45 % of variation compared to corresponding NT