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Table 1 Variations of brain amyloid peptide level in phosphoramidon-treated and control mice after 5-HIAA or vehicle treatment

From: 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease

  Vehicle 5-HIAA Phosphoramidon 5-HIAA + Phosphoramidon  
Aβ42 1.2 0.8 2.9 2.4 Mean (pg/total proteins)
100 68 244 199 Mean compared with vehicle (%)
0 −32 144 99 % of variation compared to Vehicle
−144 − 176 0 −45 % of variation compared to Phosphoramidon
Aβ40 8.4 7.2 11.7 10.5 Mean (pg/total proteins)
100 86 140 125 Mean compared with vehicle (%)
0 −14 40 25 % of variation compared to Vehicle
−39 −54 0 −15 % of variation compared to phosphoramidon