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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

Fig. 9

Riluzole and Ivermectin modulate HSR in sod1 and C9orf72 zebrafish. (a) Treatment with either 10 μM riluzole or 1 μM ivermectin from 2 to 5 dpf resulted in a significant reduction in DsRed fluorescence in sod1 zebrafish, as compared to DMSO treatment. N = 30 riluzole treated, 23 ivermectin treated and 43 DMSO treated individual zebrafish. (b) Treatment with either 10 μM riluzole or 1 μM ivermectin from 2 to 5 dpf resulted in a significant reduction in DsRed fluorescence in C9orf72 zebrafish (2.2–7 line), as compared to DMSO treatment. N = 34 riluzole treated, 34 ivermectin treated and 33 DMSO treated individual zebrafish. All data are shown as mean +/− standard deviation; *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001

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