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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats

Fig. 3

Overexpression of UBQLN2P497H in motor neurons significantly decreased the mobility of rats. a-b Photos of dystrophic hind limbs in ChATtTA/UBQLN2P497H (P497H) (a) but not in ChATtTA rats (b) at 12 months old. A red arrow points to the dystrophic hind limb in a P497H rat compared to a normal hind limb in a ChATtTA rat (yellow arrow). c A graph of the weights of gastrocnemius muscles in the P497H and ChATtTA male rats at 1 month, 6 months and 12 months old. d The body weights of P497H and ChATtTA male rats. e Analysis of the open-field test shows the distance traveled during a 10-min trial. f Analysis of the rotarod test shows the latency to fall. The data are reported as the mean ± standard deviation (n = 4, male rats were used)

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