Fig. 3
From: Novel BRAF alteration in desmoplastic infantile ganglioglioma with response to targeted therapy
In Silico Protein Modeling. a Wild-type BRAF kinase domain. Cyan indicates αC helix; gold, activation loop. Residues affected by novel indel are colored according to type of atom. b Normal activation mechanism of wild-type BRAF protein. c BRAF V600E constitutively active variant. d Novel BRAF indel with changes to numerous amino acids in the kinase domain activation loop, consistent with a kinase-active conformation