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Table 9 Morphological analysis of the 5xFAD mouse model

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

6 m DG
Spine numbers WT (n = 17) 5xFAD (n = 20)  
  1.25 [0.93–1.56] 1.36 [1–1.6] MW-test: p = 0.8923
Total dendritic length WT (n = 13) 5xFAD (n = 20)  
  2707 [2131–3003] 2425 [2134–2630] MW-test: p = 0.1275
1a DG
Spine numbers WT (n = 27) 5xFAD (n = 28)  
  1.54 [1.35–1.99] 1.07 [0.73–1.46] MW-test: p < 0.0001
  GluN1−/− (n = 6) 5xFAD/GluN1−/− (n = 12)  
  1.62 [1.36–1.76] 1.13 [0.96–2.02] MW-test: p = 0.325
  GluN2A−/− (n = 12) 5xFAD/GluN2A−/− (n = 10)  
  1.7 [1.36–1.98] 0.87 [0.64–1.04] MW-test: p = 0.0001
  GluN2B−/− (n = 28) 5xFAD/GluN2B−/− (n = 13)  
  1.73 [1.29–1.96] 1.33 [1.02–1.6] MW-test: p = 0.0165
Total dendritic length [μm] WT (n = 22) 5xFAD (n = 19)  
  2222 [1704–2660] 1882 [1708–2480] MW-test: p = 0.4763