Table 9 Morphological analysis of the 5xFAD mouse model

Spine numbers

WT (n = 17)

5xFAD (n = 20)

1.25 [0.93–1.56]

1.36 [1–1.6]

MW-test: p = 0.8923

Total dendritic length

WT (n = 13)

5xFAD (n = 20)

2707 [2131–3003]

2425 [2134–2630]

MW-test: p = 0.1275

Spine numbers

WT (n = 27)

5xFAD (n = 28)

1.54 [1.35–1.99]

1.07 [0.73–1.46]

MW-test: p < 0.0001

GluN1^−/− (n = 6)

5xFAD/GluN1^−/− (n = 12)

1.62 [1.36–1.76]

1.13 [0.96–2.02]

MW-test: p = 0.325

GluN2A^−/− (n = 12)

5xFAD/GluN2A^−/− (n = 10)

1.7 [1.36–1.98]

0.87 [0.64–1.04]

MW-test: p = 0.0001

GluN2B^−/− (n = 28)

5xFAD/GluN2B^−/− (n = 13)

1.73 [1.29–1.96]

1.33 [1.02–1.6]

MW-test: p = 0.0165

Total dendritic length [μm]

WT (n = 22)

5xFAD (n = 19)

2222 [1704–2660]

1882 [1708–2480]

MW-test: p = 0.4763