NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

Table 1 mEPSC recordings of CT100-overexpressing DG granule cells

Adult mice
3w pi	Control (n = 22)		CT100 (n = 11)
Frequency [Hz]	0.59 [0.37–0.77]		0.48 [0.44–0.71]		MW test: p = 0.9074
10w pi	Control (n = 40)		CT100 (n = 19)
Frequency [Hz]	0.71 [0.4–0.92]		0.54 [0.42–0.77]		MW test p = 0.21
Young mice
9w pi	Control (n = 56)		CT100 (n = 26)
Frequency [Hz]	0.81 [0.51–1.02]		0.61 [0.41–0.81]		MW test: p = 0.047
GluN1^fl/fl 9w pi	Control (n = 34)	CT100 (n = 10)	GluN1^−/− (n = 21)	GluN1^−/− + CT100 (n= 9)
Frequency [Hz]	0.69 [0.55–0.83]	0.37 [0.32–0.55]	0.99 [0.76–1.22]	1.18 [1.08–1.47]	Kruskal-Wallis: p < 0.0001; Dunn’s posttest: control vs CT100 p = 0.04; control vs GluN1^−/−p = 0.0045; GluN1^−/− vs GluN1^−/− + CT100 p = 0.7895
Amplitude [pA]	10.47 [9.27–11.53]	10.47 [9.94–11.53]	14.85 [12.96–16.09]	12.4 [10.99–13.81]	Kruskal-Wallis: p < 0.0001; Dunn’s posttest: control vs CT100 p > 0.9999; control vs GluN1^−/−p < 0.0001; GluN1^−/− vs GluN1^−/− + CT100 p = 0.336

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