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Table 1 mEPSC recordings of CT100-overexpressing DG granule cells

From: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

Adult mice
3w pi Control (n = 22) CT100 (n = 11)  
Frequency [Hz] 0.59 [0.37–0.77] 0.48 [0.44–0.71] MW test: p = 0.9074
10w pi Control (n = 40) CT100 (n = 19)  
Frequency [Hz] 0.71 [0.4–0.92] 0.54 [0.42–0.77] MW test p = 0.21
Young mice
9w pi Control (n = 56) CT100 (n = 26)  
Frequency [Hz] 0.81 [0.51–1.02] 0.61 [0.41–0.81] MW test: p = 0.047
GluN1fl/fl 9w pi Control (n = 34) CT100 (n = 10) GluN1−/− (n = 21) GluN1−/− + CT100 (n= 9)  
Frequency [Hz] 0.69 [0.55–0.83] 0.37 [0.32–0.55] 0.99 [0.76–1.22] 1.18 [1.08–1.47] Kruskal-Wallis: p < 0.0001; Dunn’s posttest: control vs CT100 p = 0.04; control vs GluN1−/−p = 0.0045; GluN1−/− vs GluN1−/− + CT100 p = 0.7895
Amplitude [pA] 10.47 [9.27–11.53] 10.47 [9.94–11.53] 14.85 [12.96–16.09] 12.4 [10.99–13.81] Kruskal-Wallis: p < 0.0001; Dunn’s posttest: control vs CT100 p > 0.9999; control vs GluN1−/−p < 0.0001; GluN1−/− vs GluN1−/− + CT100 p = 0.336