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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis

Fig. 4

Expression of the Adgrl2 gene during early development in chicken and mouse embryos. a, b Spatiotemporal expression of Adgrl2 on a HH12 whole chick embryo (a) and on an HH18 chick dissected neural tube (b). At HH12, strong expression is seen throughout the neural tube while weak expression is observed in the diencephalon and isthmocerebellar region (black bracket). At HH18, strong expression is still present in the telencephalon, mesencephalon and cerebellum. Very low expression is still observed in the diencephalon and isthmocerebellar region (black bracket). c Similar strong expression of Adgrl2 is observed in the telencephalon, mesencephalon and cerebellum of a 9.5 mouse embryo. di: diencephalon; cb: cerebellum; mes: mesencephalon; ot: otic vesicle; r0: isthmic organizer region; r1: rhombomere 1; rh: rhombencephalon; tel.: telencephalon

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