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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis

Fig. 2

Histological hallmarks of brain lesions. a Histological section passing through the medulla, where the olivary nuclei are poorly convoluted and hypoplastic (arrow) [H&E, OM × 15]. b In the most severely affected areas, the cerebellar cortex is rudimentary, with a strongly hypoplastic transient external granular cell layer (white arrow) [H&E, OM × 100]. c With higher magnification, almost no discernible Purkinje cell and internal granular cell layers [H&E, OM × 200]. d Focally missing Purkinje cells in the less affected areas (black arrow) [anti-calbindin immunolabelling, OM × 100]. e Thin six-layered cortical plate [H&E, OM × 25]. f Comparison with the control brain, where the cortical plate is thicker, with a higher density of neurons [H&E, OM × 25]. g Anti-MAP2 immunohistochemistry revealing numerous persistent migrating neurons in the intermediate zone [OM × 400]. h Hypoplastic hippocampi, the dentate gyrus being reduced to a small mass of granular neurons (arrow) [H&E, OM × 25]. H&E: haematoxylin-eosin staining. OM: original magnification

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