Fig. 4
From: Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET
Regional Quantitative Comparisons of [18F]Flortaucipir SUVR in PRNP F198S GSS Patients Relative to Early-Onset Alzheimer’s Patients and Cognitively Normal Older Adults. Both PRNP F198S GSS patients showed increased mean [18F]flortaucipir SUVR in subcortical areas, including the striatum (a) and thalamus (b) relative to early-onset Alzheimer’s disease (EOAD) patients and cognitively normal (CN) individuals. Cortical areas such as the insula (c), anterior cingulate gyrus (d), posterior cingulate gyrus (e), and cortex global value (h) also showed increased mean [18F]flortaucipir SUVR in the PRNP F198S GSS participants relative to the CN individuals, but not the EOAD patients