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Table 3 PAR immunoreactivity in patients with no known neurological disease

From: Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

# Diagnosis Region analyzed PAR in MN nuclei PAR in MN cytoplasm
1 normal cervical 0 0
2 normal cervical 0 ++
3 normal cervical ++ ++
4 normal cervical 0 ++
5 normal cervical 0 0
6 normal cervical 0 ++
7 normal lumbar + +
8 normal cervical 0 +
9 normal lumbar 0 ++
10 normal cervical 0 ++
11 normal cervical 0 ++
12 normal cervical 0 ++
13 normal cervical ++ ++
14 normal thoracic 0 ++
15 normal cervical 0 ++
16 normal cervical 0 ++
  1. Abbreviations: #: case number. Normal diagnosed neurologically normal. F female, M, male. PAR poly(ADP-ribose). MN motor neuron