Fig. 5
From: RNA binding proteins co-localize with small tau inclusions in tauopathy
RBPs show granularization and interfacing with NFTs in late stage human AD tissue. Immunohistochemical analysis of human AD frontal cortex tissue (n = 6) shows that RBPs (red) and NFTs stained with CP13 tau (green) do not colocalize (r = 0.001 for DDX6; 0.176 for eIF2α; 0.031 for HNRNPA0; and 0.222 for PABP). However, trace analyses across lines within the image (yellow bars) indicate that peak fluorescent intensities (reported as fluorescence intensity plots over the distance of the line for tau in green and the RBP in red) between phospho-tau and multiple RBPs are immediately adjacent to each other, indicating protein interfacing or interaction between the edges of NFTs and RBPs