Fig. 6
From: E90 subunit vaccine protects mice from Zika virus infection and microcephaly
Vaccination with E90 protects mice against ZIKV infection for up to 140 days. a. Schematic for the immunizations of CD1 (ICR) female mice with subsequent testing between day 130 (D130) to day 142 (D142), treatment with anti-Ifanr1 antibody at D135, and ZIKV infection at D136. Viremia was measured at D140 and viral loads in organs were measured at D142. b-c. The anti-ZIKV titers were quantified by ELISA (b) or PRNT (c) in mice at D130. d. ZIKV viremia in mice measured at D140. e-f. Levels of ZIKV RNA recovered from the spleens (e) and brains (f) of ZIKV-infected mice. PBS, n = 4; E90, n = 3 or 4. All data are means ± SEM. Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001