Fig. 1
From: E90 subunit vaccine protects mice from Zika virus infection and microcephaly
ZIKV E protein-based vaccine E90 prevents ZIKV infection in adult mice: a. ZIKV-specific IgG titers were analyzed at 14 and 28 days post-vaccination in mice. b. The ZIKV-neutralizing activity of serum from E90-immunized mice (2 weeks after a single boost) was analyzed by standard plaque reduction neutralization test (PRNT). c. ZIKV copies in serum from E90-immunized CD1 mice 1 day after ZIKV challenge (GZ01 strain, 105 PFU/mouse) were analyzed by qRT-PCR. PBS, n = 6; E90, n = 5. All data are means ± SEM. Student’s t-test. **p < 0.01. d. Schematic for the immunizations of CD1 (ICR) female mice and the two models for testing the protection effect in offspring. e. Virus titers used in the prenatal and postnatal models