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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: The involvement of tau in nucleolar transcription and the stress response

Fig. 4

Cellular stress induces nuclear accummulation of P-Tau which does not colocalise with nucleolar markers. Representative immunofluorescence fluorescence images showing labelling for P-Tau and T-Tau control and following glutamate treatment. Graphs show quantification from four independent experiments, each with five images and each containing an average of 40 cells. Immunofluorescence microscopy showed a significant increase in nuclear levels of P-Tau (a) and T-Tau (b). T-Tau: [P < 0.0001] and P-Tau: [P < 0.0001]. Double labelling revealed that the nuclear P-Tau does not colocalise with FBL (c) or nP-Tau (d). N ≥ 4

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