Fig. 1
From: The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease
Pathological analysis of the presubiculum in familial and sporadic Alzheimer’s disease (AD; a-f), familial British dementia (FBD; g-i) and familial Danish dementia (FDD; j-l). Aβ immunohistochemistry demonstrates large diffuse, ‘lake-like’ deposits in the presubiculum in both familial AD (case 26; a, arrow; b, presubiculum at higher magnification) and sporadic AD (case 2; d, arrow; e presubiculum at higher magnification). In both disease types well-defined Aβ plaques were present in the entorhinal cortex as shown in sporadic AD (c and f). The ABri-positive (case 31; g-i) and ADan-positive (case 36; j-l) parenchymal deposits show similar morphological patterns in FBD and FDD, respetively. Bar in a represents 1000 μm in a,d,g, and j; 50 μm in all remaining images