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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs

Fig. 4

piRNAs are differentially expressed during induction of pluripotency and neuronal differentiation. a Analysis of differential mature miRNA and piRNA expression by DESeq2 in control-patient derived cells. During induction of pluripotency and neuronal differentiation, piRNAs are as dynamically regulated as mature miRNAs. b TOP20 most highly expressed (sorted by base mean as calculated by DESeq2) and differentially regulated piRNAs in the comparison iPSC/ESC vs. neuron in control-patient derived cells. c Pie chart of the genomic elements from which the differentially regulated piRNAs in the comparison iPSC/ESC vs. neuron are derived. SINE-derived piRNAs are significantly enriched in the fraction of deregulated piRNAs as compared to their genome-wide abundance among all piRNAs annotated by piRBase, which is set to one (two-sided chi-square test, p < 0.0001). d Heatmap and hierarchical clustering based on the TOP100 differentially expressed piRNAs in control iPSCs/ESCs vs. neurons (sorted by adjusted p-value). Neurons (azure) are nicely separated from iPSCs (yellow) and ESCs (gold)

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