Fig. 2

‘Heat map’ illustrating the onset and progression of amyloid plaque, CAA and tau pathology across the different brain regions for the 56 cases of Down syndrome. Box colours indicate increasing severity of pathological change from blue through to red. Numbers in boxes are derived from scoring systems described in the text. Tcx = temporal cortex, Fcx = frontal cortex, Ocx = occipital cortex, Ecx = entorhinal cortex, h = molecular layer of hippocampus, CA1 = CA1 region of hippocampus, DG = dentate gyrus of hippocampus, CS = corpus striatum, LC = locus coeruleus, DRN = dorsal raphe nucleus, SN = substantia nigra, CBM = cerebellum, Ab = amyloid deposits (plaques), CAA = cerebral amyloid angiopathy, tau = tau tangles