From: Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma
GO Terms: Top genes down in PC1 (up in DIPG/aGBM) | ||
GO Term | p-value | Genes |
Cell adhesion | 3.178E-08 | IBSP, CD9, PLXNC1, CD44, TGFBI, VCAN, ACKR3, THBS1, GPNMB, EMILIN2, CD72, FN1 |
Angiogenesis | 2.285E-06 | VAV3, EREG, TGFBI, MMP19, CXCL8, ACKR3, ANPEP, FN1 |
Extracellular matrix organization | 1.488E-05 | IBSP, CD44, DMP1, TGFBI, VCAN, THBS1, FN1 |
Platelet degranulation | 1.787E-04 | CD9, ACTN1, THBS1, FLNA, FN1 |
Peptide cross-linking | 3.446E-04 | ANXA1, TGM2, THBS1, FN1 |
Neutrophil chemotaxis | 7.802E-04 | VAV3, LGALS3, CXCL8, TREM1 |
Movement of cell or subcellular component | 1.679E-03 | CD9, VIM, CXCL8, FPR3 |
Platelet activation | 3.834E-03 | CD9, VAV3, ACTN1, FLNA |
GO Terms: Top genes down in PC2 (up in aGBM) | ||
GO Term | p-value | Genes |
Monocyte chemotaxis | 3.14E-08 | IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4 |
Inflammatory response | 9.84E-08 | PLP1, IL6, CCL3, CCL2, CCL3L1, CXCL9, IL1B, CCL4L2, CCL4, IL1A |
Immune response | 2.40E-07 | IL6, CCL3, CCL2, ENPP2, FCGR1B, CXCL9, IL1B, CCL4L2, CCL4, IL1A |
Neutrophil chemotaxis | 3.18E-07 | CCL3, CCL2, CCL3L1, IL1B, CCL4L2, CCL4 |
Cellular response to interleukin-1 | 4.60E-07 | IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4 |
Chemokine-mediated signaling pathway | 4.60E-07 | CCL3, CCL2, CCL3L1, CXCL9, CCL4L2, CCL4 |
Positive regulation of ERK1 and ERK2 cascade | 2.09E-06 | IL6, CCL3, CCL2, CCL3L1, CCL4L2, FGF1, CCL4 |
Cellular response to tumor necrosis factor | 4.06E-06 | IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4 |