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Table 1 Gene-ontology terms associated with the top 50 genes contributing to principal component 1 (top) or principal component 2 (bottom)

From: Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma

GO Terms: Top genes down in PC1 (up in DIPG/aGBM)

 GO Term

p-value

Genes

  Cell adhesion

3.178E-08

IBSP, CD9, PLXNC1, CD44, TGFBI, VCAN, ACKR3, THBS1, GPNMB, EMILIN2, CD72, FN1

  Angiogenesis

2.285E-06

VAV3, EREG, TGFBI, MMP19, CXCL8, ACKR3, ANPEP, FN1

  Extracellular matrix organization

1.488E-05

IBSP, CD44, DMP1, TGFBI, VCAN, THBS1, FN1

  Platelet degranulation

1.787E-04

CD9, ACTN1, THBS1, FLNA, FN1

  Peptide cross-linking

3.446E-04

ANXA1, TGM2, THBS1, FN1

  Neutrophil chemotaxis

7.802E-04

VAV3, LGALS3, CXCL8, TREM1

  Movement of cell or subcellular component

1.679E-03

CD9, VIM, CXCL8, FPR3

  Platelet activation

3.834E-03

CD9, VAV3, ACTN1, FLNA

GO Terms: Top genes down in PC2 (up in aGBM)

 GO Term

p-value

Genes

  Monocyte chemotaxis

3.14E-08

IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4

  Inflammatory response

9.84E-08

PLP1, IL6, CCL3, CCL2, CCL3L1, CXCL9, IL1B, CCL4L2, CCL4, IL1A

  Immune response

2.40E-07

IL6, CCL3, CCL2, ENPP2, FCGR1B, CXCL9, IL1B, CCL4L2, CCL4, IL1A

  Neutrophil chemotaxis

3.18E-07

CCL3, CCL2, CCL3L1, IL1B, CCL4L2, CCL4

  Cellular response to interleukin-1

4.60E-07

IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4

  Chemokine-mediated signaling pathway

4.60E-07

CCL3, CCL2, CCL3L1, CXCL9, CCL4L2, CCL4

  Positive regulation of ERK1 and ERK2 cascade

2.09E-06

IL6, CCL3, CCL2, CCL3L1, CCL4L2, FGF1, CCL4

  Cellular response to tumor necrosis factor

4.06E-06

IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4