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Table 1 Gene-ontology terms associated with the top 50 genes contributing to principal component 1 (top) or principal component 2 (bottom)

From: Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma

GO Terms: Top genes down in PC1 (up in DIPG/aGBM)
 GO Term p-value Genes
  Cell adhesion 3.178E-08 IBSP, CD9, PLXNC1, CD44, TGFBI, VCAN, ACKR3, THBS1, GPNMB, EMILIN2, CD72, FN1
  Angiogenesis 2.285E-06 VAV3, EREG, TGFBI, MMP19, CXCL8, ACKR3, ANPEP, FN1
  Extracellular matrix organization 1.488E-05 IBSP, CD44, DMP1, TGFBI, VCAN, THBS1, FN1
  Platelet degranulation 1.787E-04 CD9, ACTN1, THBS1, FLNA, FN1
  Peptide cross-linking 3.446E-04 ANXA1, TGM2, THBS1, FN1
  Neutrophil chemotaxis 7.802E-04 VAV3, LGALS3, CXCL8, TREM1
  Movement of cell or subcellular component 1.679E-03 CD9, VIM, CXCL8, FPR3
  Platelet activation 3.834E-03 CD9, VAV3, ACTN1, FLNA
GO Terms: Top genes down in PC2 (up in aGBM)
 GO Term p-value Genes
  Monocyte chemotaxis 3.14E-08 IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4
  Inflammatory response 9.84E-08 PLP1, IL6, CCL3, CCL2, CCL3L1, CXCL9, IL1B, CCL4L2, CCL4, IL1A
  Immune response 2.40E-07 IL6, CCL3, CCL2, ENPP2, FCGR1B, CXCL9, IL1B, CCL4L2, CCL4, IL1A
  Neutrophil chemotaxis 3.18E-07 CCL3, CCL2, CCL3L1, IL1B, CCL4L2, CCL4
  Cellular response to interleukin-1 4.60E-07 IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4
  Chemokine-mediated signaling pathway 4.60E-07 CCL3, CCL2, CCL3L1, CXCL9, CCL4L2, CCL4
  Positive regulation of ERK1 and ERK2 cascade 2.09E-06 IL6, CCL3, CCL2, CCL3L1, CCL4L2, FGF1, CCL4
  Cellular response to tumor necrosis factor 4.06E-06 IL6, CCL3, CCL2, CCL3L1, CCL4L2, CCL4