Table 2 Clinical, radiographic, and histologic features of 40 gangliogliomas stratified by genetic alterations
Clinicopathologic features | BRAF V600E (n = 18) | BRAF other alteration (n = 9) | BRAF any alteration (n = 27) | BRAF wildtype (n = 13) | FGFR alteration (n = 5) | Total cohort (n = 40) | |
|---|---|---|---|---|---|---|---|
Age (years), median (range) |  | 15 (3–63) | 17 (5–41) | 15 (3–63) | 32 (0–59) | 35 (7–59) | 21 (0–63) |
Male: Female | Â | 13:5 | 2:7 | 15:12 | 8:5 | 3:2 | 23:17 |
Location: | Cerebrum | 13 (72%) | 7 (78%) | 20 (74%) | 11 (85%) | 5 (100%) | 31 (78%) |
| Â | Cerebellum | 3 (17%) | 0 (0%) | 3 (11%) | 1 (8%) | 0 (0%) | 4 (10%) |
| Â | Thalamus | 2(11%) | 0 (0%) | 2 (7%) | 0 (0%) | 0 (0%) | 2 (5%) |
| Â | Spinal cord | 0 (0%) | 2 (22%) | 2 (7%) | 1 (8%) | 0 (0%) | 3 (8%) |
Imaging features1 | |||||||
 Size (cm), median (range) |  | 3.1 (2.0–5.9) | 5.1 (1.8–7.1) | 3.6 (1.8–7.1) | 2.9 (1.3–16.0) | 4.8 (1.3–9.6) | 3.4 (1.3–16.0) |
 Cystic component |  | 9/11 (82%) | 6/8 (75%) | 15/19 (79%) | 8/10 (80%) | 3/4 (75%) | 23/29 (79%) |
 Well-circumscribed |  | 3/11 (27%) | 5/8 (63%) | 8/19 (42%) | 5/10 (50%) | 2/4 (50%) | 13/29 (45%) |
Histologic features | |||||||
 Glial component: | Oligodendroglial | 0 (0%) | 0 (0%) | 0 (0%) | 3 (23%) | 3 (60%)2 | 3 (8%) |
| Â | Astrocytic | 18 (100%) | 9 (100%) | 27 (100%) | 10 (77%) | 2 (40%) | 37 (92%) |
 Eosinophilic granular bodies |  | 13 (72%) | 6 (67%) | 19 (70%) | 8 (62%) | 3 (60%) | 27 (68%) |
 Rosenthal fibers |  | 1 (6%) | 1 (11%) | 2 (7%) | 4 (31%) | 1 (20%) | 6 (15%) |
 Calcifications |  | 9 (50%) | 4 (44%) | 13 (48%) | 6 (46%) | 3 (60%) | 19 (48%) |
 Perivascular lymphocytes |  | 11 (61%) | 8 (89%) | 19 (70%) | 4 (31%) | 1 (20%) | 23 (58%) |