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Table 1 Summary of the clinicopathologic features and molecular alterations in the ganglioglioma patient cohort

From: The genetic landscape of ganglioglioma

Tumor ID Age/sex Tumor location Presenting symptoms Radiographic pattern Glial component Pathogenic genetic alterations identified Chromosomal gains/losses Extent of resection Recurrence or progression Time to recurrence or progression (years) Length of follow-up (years)
SF-GG-01 5 M Temporal lobe seizures cystic and solid astrocytic BRAF p.V600E none gross total no 0.1 0.1
SF-GG-02 8 M Occipital lobe seizures multicystic astrocytic BRAF p.V600E none gross total no 0.4 0.4
SF-GG-03 14 M Occipital lobe seizures N/A astrocytic BRAF p.V600E, CDKN2A/B HD, PTEN p.R173C (s) +distal 3q, − 9 gross total yes (P) 1.8 1.8
SF-GG-04 11 M Temporal lobe seizures N/A astrocytic BRAF p.V600E none subtotal yes (R) 4.4 4.4
SF-GG-05 12 F Temporal lobe seizures N/A astrocytic BRAF p.V600E + 7, + 9, + 12 unknown yes (P) 1.8 1.8
SF-GG-06 12 F Temporal lobe seizures cystic and solid astrocytic BRAF p.V600E none gross total no 0.5 0.5
SF-GG-07 30 M Temporal lobe seizures N/A astrocytic BRAF p.V600E -1p, −16q gross total no 0.0 0.0
SF-GG-08 27 M Temporal lobe seizures N/A astrocytic BRAF p.V600E + 5, + 7, + 8, + 11, + 12, + 15, + 16, + 19, + 20, + 21 gross total no 0.1 0.1
SF-GG-09 34 M Temporal lobe seizures solid astrocytic BRAF p.V600E, CDKN2A/B HD -9 gross total no 0.4 0.4
SF-GG-10 37 M Temporal lobe seizures N/A astrocytic BRAF p.V600E + 5 gross total no 9.4 9.4
SF-GG-11 25 F Temporal lobe seizures cyst with mural nodule astrocytic BRAF p.V600E, CDKN2A/B HD -1p, −9 gross total no 6.7 6.7
SF-GG-12 41 F Temporal lobe seizures cystic and solid astrocytic BRAF p.V600E none gross total no 9.2 9.2
SF-GG-13 63 M Parietal lobe seizures cyst with mural nodule astrocytic BRAF p.V600E -1p, +19p gross total no 0.0 0.0
SF-GG-14 15 F Cerebellum headaches cystic and solid astrocytic BRAF p.V600E none gross total no 14.8 14.8
SF-GG-15 13 M Cerebellum asymptomatic complex heterogeneous astrocytic BRAF p.V600E none subtotal yes (P) 10.4 10.4
SF-GG-16 30 F Cerebellum nystagmus complex heterogeneous astrocytic BRAF p.V600E none subtotal no 13.8 13.8
SF-GG-17 8 M Thalamus headache complex heterogeneous astrocytic BRAF p.V600E none biopsy no 0.0 0.0
SF-GG-18 12 M Thalamus dystonia N/A astrocytic BRAF p.V600E none biopsy yes (P) 29.3 29.3
SF-GG-19 7 M Occipital lobe seizures cyst with mural nodule astrocytic BRAF p.T599_W604delinsTDG none gross total no 14.1 14.1
SF-GG-20 19 F Temporal lobe seizures solid astrocytic BRAF p.R506delinsRVLR none gross total no 0.2 0.2
SF-GG-21 29 M Temporal lobe seizures cystic and solid astrocytic BRAF p.R506delinsRSTQ + 5, + 6, + 7, + 11, + 18 subtotal no 1.8 1.8
SF-GG-22 23 F Temporal lobe seizures cyst with mural nodule astrocytic BRAF p.L505delinsLEYLS none unknown no 0.0 0.0
SF-GG-23 41 F Parietal lobe visual distortion solid multinodular astrocytic BRAF p.R506delinsRVLR none gross total yes (P) 8.1 8.1
SF-GG-24 5 F Spinal cord asymptomatic cystic and solid astrocytic KIAA1549-BRAF fusion none subtotal no 0.2 0.2
SF-GG-25 17 F Spinal cord leg weakness complex heterogeneous astrocytic KIAA1549-BRAF fusion none gross total no 4.5 4.5
SF-GG-26 9 F Temporal lobe seizures complex heterogeneous astrocytic CDC42BPB-BRAF fusion -interstitial 17p subtotal yes (R) 2.2 2.2
SF-GG-27 8 F Occipital lobe seizures solid astrocytic KLHL7-BRAF fusion + 7 gross total no 1.4 1.4
SF-GG-28 48 M Frontal lobe seizures cyst with mural nodule astrocytic ERC2-RAF1 fusion + 3, −interstitial 3p, + 5, + 7 gross total no 0.5 0.5
SF-GG-29 32 F Insula seizures cyst with mural nodule astrocytic KRAS p.Q61K none gross total no 0.0 0.0
SF-GG-30 24 M Temporal lobe seizures cyst with mural nodule astrocytic KRAS p.Q61K none gross total no 1.0 1.0
SF-GG-31 28 M Temporal lobe headaches cystic and solid astrocytic germline NF1 p.Q514frameshift w/ somatic LOH + 4, + 5, + 7, + 8, + 9, + 12, + 15, −17p, −18p, + 22 gross total no 5.9 5.9
SF-GG-32 35 M Frontal lobe paresthesias solid oligodendroglial FGFR1-TACC1 fusion none subtotal no 1.4 1.4
SF-GG-33 59 F Temporal lobe seizures multicystic astrocytic FGFR1 p.N546 K none gross total no 5.9 5.9
SF-GG-34 7 M Temporal lobe seizures N/A oligodendroglial FGFR2-KIAA1598 fusion none gross total no 5.3 5.3
SF-GG-35 35 M Parietal lobe unknown complex heterogeneous oligodendroglial FGFR2-INA fusion -portions of 10 unknown yes (P) 9.1 9.1
SF-GG-36 37 F Parietal lobe leg weakness N/A astrocytic FGFR2 exon 17 splice site mutation none subtotal no 7.5 7.5
SF-GG-37 2 M Frontal lobe seizures microcystic astrocytic ABL2-GAB2 fusion none subtotal no 0.3 0.3
SF-GG-38 53 F Occipital lobe asymptomatic N/A astrocytic none identified none gross total no 0.0 0.0
SF-GG-39 0 F Cerebellum nystagmus cystic and solid astrocytic none identified none gross total no 14.9 14.9
SF-GG-40 10 M Spinal cord arm weakness N/A astrocytic none identified none gross total no 14.3 14.3
  1. HD Homozygous deletion. LOH Loss of heterozygosity. (s), subclonal. (R), radiographic recurrence/progression. (P), pathologically confirmed recurrence/progression