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Table 1 Summary of the clinicopathologic features and molecular alterations in the ganglioglioma patient cohort

From: The genetic landscape of ganglioglioma

Tumor ID

Age/sex

Tumor location

Presenting symptoms

Radiographic pattern

Glial component

Pathogenic genetic alterations identified

Chromosomal gains/losses

Extent of resection

Recurrence or progression

Time to recurrence or progression (years)

Length of follow-up (years)

SF-GG-01

5 M

Temporal lobe

seizures

cystic and solid

astrocytic

BRAF p.V600E

none

gross total

no

0.1

0.1

SF-GG-02

8 M

Occipital lobe

seizures

multicystic

astrocytic

BRAF p.V600E

none

gross total

no

0.4

0.4

SF-GG-03

14 M

Occipital lobe

seizures

N/A

astrocytic

BRAF p.V600E, CDKN2A/B HD, PTEN p.R173C (s)

+distal 3q, − 9

gross total

yes (P)

1.8

1.8

SF-GG-04

11 M

Temporal lobe

seizures

N/A

astrocytic

BRAF p.V600E

none

subtotal

yes (R)

4.4

4.4

SF-GG-05

12 F

Temporal lobe

seizures

N/A

astrocytic

BRAF p.V600E

+ 7, + 9, + 12

unknown

yes (P)

1.8

1.8

SF-GG-06

12 F

Temporal lobe

seizures

cystic and solid

astrocytic

BRAF p.V600E

none

gross total

no

0.5

0.5

SF-GG-07

30 M

Temporal lobe

seizures

N/A

astrocytic

BRAF p.V600E

-1p, −16q

gross total

no

0.0

0.0

SF-GG-08

27 M

Temporal lobe

seizures

N/A

astrocytic

BRAF p.V600E

+ 5, + 7, + 8, + 11, + 12, + 15, + 16, + 19, + 20, + 21

gross total

no

0.1

0.1

SF-GG-09

34 M

Temporal lobe

seizures

solid

astrocytic

BRAF p.V600E, CDKN2A/B HD

-9

gross total

no

0.4

0.4

SF-GG-10

37 M

Temporal lobe

seizures

N/A

astrocytic

BRAF p.V600E

+ 5

gross total

no

9.4

9.4

SF-GG-11

25 F

Temporal lobe

seizures

cyst with mural nodule

astrocytic

BRAF p.V600E, CDKN2A/B HD

-1p, −9

gross total

no

6.7

6.7

SF-GG-12

41 F

Temporal lobe

seizures

cystic and solid

astrocytic

BRAF p.V600E

none

gross total

no

9.2

9.2

SF-GG-13

63 M

Parietal lobe

seizures

cyst with mural nodule

astrocytic

BRAF p.V600E

-1p, +19p

gross total

no

0.0

0.0

SF-GG-14

15 F

Cerebellum

headaches

cystic and solid

astrocytic

BRAF p.V600E

none

gross total

no

14.8

14.8

SF-GG-15

13 M

Cerebellum

asymptomatic

complex heterogeneous

astrocytic

BRAF p.V600E

none

subtotal

yes (P)

10.4

10.4

SF-GG-16

30 F

Cerebellum

nystagmus

complex heterogeneous

astrocytic

BRAF p.V600E

none

subtotal

no

13.8

13.8

SF-GG-17

8 M

Thalamus

headache

complex heterogeneous

astrocytic

BRAF p.V600E

none

biopsy

no

0.0

0.0

SF-GG-18

12 M

Thalamus

dystonia

N/A

astrocytic

BRAF p.V600E

none

biopsy

yes (P)

29.3

29.3

SF-GG-19

7 M

Occipital lobe

seizures

cyst with mural nodule

astrocytic

BRAF p.T599_W604delinsTDG

none

gross total

no

14.1

14.1

SF-GG-20

19 F

Temporal lobe

seizures

solid

astrocytic

BRAF p.R506delinsRVLR

none

gross total

no

0.2

0.2

SF-GG-21

29 M

Temporal lobe

seizures

cystic and solid

astrocytic

BRAF p.R506delinsRSTQ

+ 5, + 6, + 7, + 11, + 18

subtotal

no

1.8

1.8

SF-GG-22

23 F

Temporal lobe

seizures

cyst with mural nodule

astrocytic

BRAF p.L505delinsLEYLS

none

unknown

no

0.0

0.0

SF-GG-23

41 F

Parietal lobe

visual distortion

solid multinodular

astrocytic

BRAF p.R506delinsRVLR

none

gross total

yes (P)

8.1

8.1

SF-GG-24

5 F

Spinal cord

asymptomatic

cystic and solid

astrocytic

KIAA1549-BRAF fusion

none

subtotal

no

0.2

0.2

SF-GG-25

17 F

Spinal cord

leg weakness

complex heterogeneous

astrocytic

KIAA1549-BRAF fusion

none

gross total

no

4.5

4.5

SF-GG-26

9 F

Temporal lobe

seizures

complex heterogeneous

astrocytic

CDC42BPB-BRAF fusion

-interstitial 17p

subtotal

yes (R)

2.2

2.2

SF-GG-27

8 F

Occipital lobe

seizures

solid

astrocytic

KLHL7-BRAF fusion

+ 7

gross total

no

1.4

1.4

SF-GG-28

48 M

Frontal lobe

seizures

cyst with mural nodule

astrocytic

ERC2-RAF1 fusion

+ 3, −interstitial 3p, + 5, + 7

gross total

no

0.5

0.5

SF-GG-29

32 F

Insula

seizures

cyst with mural nodule

astrocytic

KRAS p.Q61K

none

gross total

no

0.0

0.0

SF-GG-30

24 M

Temporal lobe

seizures

cyst with mural nodule

astrocytic

KRAS p.Q61K

none

gross total

no

1.0

1.0

SF-GG-31

28 M

Temporal lobe

headaches

cystic and solid

astrocytic

germline NF1 p.Q514frameshift w/ somatic LOH

+ 4, + 5, + 7, + 8, + 9, + 12, + 15, −17p, −18p, + 22

gross total

no

5.9

5.9

SF-GG-32

35 M

Frontal lobe

paresthesias

solid

oligodendroglial

FGFR1-TACC1 fusion

none

subtotal

no

1.4

1.4

SF-GG-33

59 F

Temporal lobe

seizures

multicystic

astrocytic

FGFR1 p.N546 K

none

gross total

no

5.9

5.9

SF-GG-34

7 M

Temporal lobe

seizures

N/A

oligodendroglial

FGFR2-KIAA1598 fusion

none

gross total

no

5.3

5.3

SF-GG-35

35 M

Parietal lobe

unknown

complex heterogeneous

oligodendroglial

FGFR2-INA fusion

-portions of 10

unknown

yes (P)

9.1

9.1

SF-GG-36

37 F

Parietal lobe

leg weakness

N/A

astrocytic

FGFR2 exon 17 splice site mutation

none

subtotal

no

7.5

7.5

SF-GG-37

2 M

Frontal lobe

seizures

microcystic

astrocytic

ABL2-GAB2 fusion

none

subtotal

no

0.3

0.3

SF-GG-38

53 F

Occipital lobe

asymptomatic

N/A

astrocytic

none identified

none

gross total

no

0.0

0.0

SF-GG-39

0 F

Cerebellum

nystagmus

cystic and solid

astrocytic

none identified

none

gross total

no

14.9

14.9

SF-GG-40

10 M

Spinal cord

arm weakness

N/A

astrocytic

none identified

none

gross total

no

14.3

14.3

  1. HD Homozygous deletion. LOH Loss of heterozygosity. (s), subclonal. (R), radiographic recurrence/progression. (P), pathologically confirmed recurrence/progression