Fig. 1.
From: Interrupted CAG expansions in ATXN2 gene expand the genetic spectrum of frontotemporal dementias
Brain imaging and pathology. Left: Brain MRI and CT scan and HMPAO-SPECT examination of patient 5 (aged 73 years). a. Brain T1 axial sections showing marked bilateral frontal atrophy, associated with predominantly left parietal atrophy (arrows). b. T1 axial and coronal sections, showing no cerebellar atrophy. c. brain CT scan (axial sections) showing predominantly left peri-sylvian and frontal atrophy (arrows). d. HMPAO-SPECT examination (axial and coronal sections) showing bilateral, predominantly left (arrow), hypoperfusion. L: left; R: right. Right: Brain pathological lesions of patient 5. e. Cerebellum. Haematoxylin-Eosin stain. Normal density of Purkinje cells, of granule cells and of glomeruli. f. Dentate gyrus. Phospho-TDP-43 immunohistochemistry. Neuronal cytoplasmic inclusion. g. Upper layers of the middle frontal gyrus. Phospho-TDP-43 immunohistochemistry. Several cytoplasmic inclusions (short arrows) in glial cells. One phospho-TDP-43 positive neurite (long arrow). h. Middle frontal gyrus. Phospho-TDP-43immunohistochemistry. Neuronal cytoplasmic inclusion. i. Middle frontal gyrus. Phospho-TDP-43 immunohistochemistry. Cat-eye nuclear inclusion (arrow). j. Medulla oblongata. Neurofilamentimmunohistochemistry. Numerous axonal spheroids (arrows) in the amiculum of the inferior olives. All scale bars= 10 μm