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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Fig. 4

Tmem106b levels do not affect (GGGGCC)66 repeat induced pTdp-43 inclusion body formation. a Representative images of pTdp-43 (pS409/410 from Cosmo Bio) staining of motor cortex region of the mouse brains from indicated Tmem106b genotypes 12 months after 2R and 66R AAV injection. Arrow heads indicate pTdp-43-positive inclusion bodies. b and c Quantification of pTdp-43 inclusion body positive cells in different brain regions: cortex (b) or hippocampus (c) from Tmem106b +/+, +/−, and −/− mice as compared to WT 2R injected mice (n = 4). Graphs represent the mean ± S.E.M. Data was analyzed by one-way ANOVA followed by Fisher’s LSD post-hoc, and results are shown for 66R-injected Tmem106b +/− and −/− mice as compared to 66R-injected wild-type mice (n = 12 per group). NS, not significant

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