Fig. 4
![Fig. 4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs40478-018-0544-y/MediaObjects/40478_2018_544_Fig4_HTML.png)
Genes located in the region of the 1p/19q co-deletion with strong impact on signaling and metabolic pathways. Impacts of differentially expressed genes of the 1p/19q region on the expression of known cancer-relevant signaling pathway genes (a) and metabolic pathway genes (b). All shown genes had significantly greater impacts under the oligodendroglioma-specific gene regulatory networks than under corresponding random networks of same complexity (q-value ≤0.05). The high-impact genes are widespread across the region of the 1p/19q co-deletion. Genes colored in green were underexpressed and genes colored in red were overexpressed in oligodendrogliomas compared to normal brain tissue