Fig. 4

Genes located in the region of the 1p/19q co-deletion with strong impact on signaling and metabolic pathways. Impacts of differentially expressed genes of the 1p/19q region on the expression of known cancer-relevant signaling pathway genes (a) and metabolic pathway genes (b). All shown genes had significantly greater impacts under the oligodendroglioma-specific gene regulatory networks than under corresponding random networks of same complexity (q-value ≤0.05). The high-impact genes are widespread across the region of the 1p/19q co-deletion. Genes colored in green were underexpressed and genes colored in red were overexpressed in oligodendrogliomas compared to normal brain tissue