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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Astrocyte remodeling without gliosis precedes optic nerve axonopathy

Fig. 6

Astrocytes become more parallel as axons expand early prior to loss. a Modified from Cooper et al. [11]. CoM decreases significantly as axons expand early in the DBA/2 J nerve prior to overt loss of axons (r = 0.55, p < 0.001). b As axons expand prior to outright loss, parallelism increases (r = 0.50, p = 0.05). c Parallelism tends to increase with decreasing CoM for the same set of nerves (r = 0.47; p = 0.071). d Glial coverage of the nerve does not change as axons expand prior to loss (r = 0.006, p = 0.98). All data collected from subset of nerves with highest axon sampling density below the threshold of axon size for which loss occurs (4.8–6.5 × 105 axons/mm2; see [11])

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