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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Astrocyte remodeling without gliosis precedes optic nerve axonopathy

Fig. 5

Parallelism diminishes with markers of axon degeneration. a Parallelism decreases moderately as DBA/2 J mice age (r = − 0.293, p = 0.046); there is no correlation with the mean lifetime IOP (b; r = − 0.193, p = 0.415). c Parallelism rapidly diminishes with enlargement of the nerve (r = − 0.435, p = 0.003). d Increased mean axon area is also correlated with decreased parallelism (r = − 0.457, p = 0.001). e Parallelism demonstrates a tight correlation with diminished axon density (r = − 0.628, p < 0.001). f As the total number of axons decreases, parallelism decreases (r = − 0.427, p = 0.005)

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