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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Astrocyte remodeling without gliosis precedes optic nerve axonopathy

Fig. 1

Pathology alters glial orientation in the optic nerve. a Left: cross-section through DBA/2 J optic nerve prior to progression. Nerve has high axon packing density (6.2 × 105 axons/mm2) and low glial coverage area (11.4% of total nerve area). Right: during progression axons are lost (2.4 × 105 axons/mm2) and glial coverage increases (45.19%). b Higher magnification of inset from healthy nerve in a with highlighted glial processes demonstrating parallel orientation. c Inset from glaucomatous nerve in a with glial processes similarly highlighted. In this nerve, processes appear disordered, or oriented without a discernable pattern. Scale = 100 μm (a), 10 μm (b, c)

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